术前血清促甲状腺激素水平与甲状腺结节相关性的研究

目的：探讨术前血清促甲状腺激素（TSH）水平与甲状腺结节良恶性的关系。方法：回顾性分析了1499例甲状腺结节手术切除患者术前血清TSH、甲状腺B超，手术记录、术后病理诊断报告。根据术后病理报告判定甲状腺结节良恶性，分析术前血清TSH水平在甲状腺良恶性结节中的不同分布。结果：分化型甲状腺癌（DTC）患者术前血清TSH水平明显高于甲状腺良性结节组（2．179±2．017vsl．259±0．884μIU／mL），P〈0．001；在DTC患者中，有淋巴结转移较无淋巴结转移、TNM分期Ⅲ、Ⅳ期较Ⅰ、Ⅱ期以及肿瘤直径≥1cm较〈1cm的患者术前血清TSH明显升高（均P〈0．001）。结论：术前血清TSH水平是预测甲状腺结节良恶性的重要指标。

A Study of the Relationship between Preoperative Serum Thyrotropin Level and Thyroid Nodules

Objective： To investigate the relationship between preoperative serum thyroid stimulating hormone （TSH） levels and the benign or malignant thyroid nodules. Methods： The serum TSH level, thyroid B-Doppler ultrasound reports, surgical records, pathological diagnosis reports of 1499 thyroid nodules selected patients were retrospectively analyzed. According to pathology reports to determine the benign or malignant thyroid nodules, the different distribution between benign and malignant thyroidnodules in preoperative serum TSH levels was analyzed. Results： The preoperative serum TSH levels in patients of differentiated thyroid carcinoma （DTC） were significantly higher than those in benign thyroid nodules group （2.179：1：2.017vsl.259 ＋ 0.884μIU / ml）, P 〈0.001; In DTC patients, lymph node metastasis than those without lymph node metastasis, TNM stage Ⅲ, IV longer than I, II stage, and tumor diameter ≥ 1 em more 〈1 cm in patients with preoperative serum TSH was significantly higher （all P 〈0.001）. Conclusion： Preoperative serum TSH levels is an important indicator to whether thyroid nodules benign or malignant.