北京市老年人肝肾功能参数的参考值范围调查

目的：观察北京市60岁以上不同年龄段健康老年人肝肾功能检验项目水平的差异,建立各自的参考值范围。方法：随机挑选600例60岁以上的北京市健康老人,按照不同年龄段分为三组,空腹采血,采用Modular仪器及原装试剂测定血清ALT（丙氨酸氨基转移酶）、AST（天冬氨酸氨基转移酶）、TP（总蛋白）、ALB（白蛋白）、Bun（尿素氮）、Crea（肌酐）、UA（尿酸）水平,结果利用SPSS11.0进行统计分析,根据统计学结果,判断参考值范围,并比较不同组间水平的差异。同时随机选择371例健康青年,与老年组进行这些项目水平的比较。结果：统计学结果显示,AST、TP、UA组间无显著差异;ALT、ALB随年龄增加而下降;Bun、Crea随年龄增加而升高。结论：通过上述实验,对老年人群的ALT、AST、TP、ALB、Bun、Crea、UA等项目的参考区间进行初步分析,对现行参考区间的设定提供建议与参考。各实验室应建立自己的参考值范围。

Investigation of Reference Range of Parameters of Liver and Renal Function of Old People in Beijing

Objective： To observe the reference range of parameters which reflect liver and renal function in different age of old people in Beijing. Methods： A random sample of 600 old people were divided in three groups with different ages. The blood was drawing on empty stomach. The Modular machine and its supported reagent were used to detect the levels of ALT （alanine aminotransferase）, AST （aspartate aminotransferase）, TP（total protein）, ALB（albumin）, Bun（blood urea nitrogen）, Crea （creatinine） and UA （uric acid）. SPSS11.0 was used to analyze results and compare the levels between groups, and the reference range was decided accord to statistical results. A random sample of 371 healthy young people were compared with old people in these parameters. Results： AST, TP, UA had no significant differences in different groups, while ALT, ALB declined with age and Bun, Crea increased with age. Conclusion： Through this experiment, it will conduct the preliminary analysis on the old people＇ reference range of ALT, AST, TP, ALB, Bun, Crea, UA, and provide suggestion on the current reference range. Each clinical laboratory should establish its own reference range.