普贝生用于足月妊娠促宫颈成熟的疗效观察

目的：探讨普贝生促进宫颈成熟，提高足月妊娠经阴道分娩的有效性和安全性。方法：120例足月妊娠的未临产孕妇随机分为试验组与对照组，其中试验组50例给予阴道后穹隆置入普贝生1～2次，对照组50例给予小剂量催产素静脉滴注，比较两组宫颈成熟度，分娩情况及对于产妇、新生儿的影响。结果：①试验组宫颈Bishop评分增加3．81±1．04，对照组增加3．09±1．15，两组间差异有统计学意义（P〈0．05）②试验组促宫颈成熟的显效率为78．33％，总有效率为91．67％，高于对照组35．00％显效率和63．33％总有效率（P〈0．01）。③试验组阴道分娩率73．33％，进入产程时间（34．19±13．20）h，产程（8．47±2．68）h，对照组阴道分娩率41．67％，进入产程时间（52．14±16．05）h，产程（12．25±3．73）h，两组间比较差异有显著性（P〈0．01或0．05）。④试验组产后出血量（225．31±67．80）ml，新生儿体重（3369．48±311．65）g，Apgar评分9．52±0．39，对照组产后出血量（232．44±75．76）ml，新生儿体重（3417．63±359．68）g，Apgar评分9．48±0．47，两组间差异无统计学意义（P〉0．05）。结论：普贝生可有效促进足月妊娠产妇的宫颈成熟．提高经阴道引产成功率，降低剖宫产率，且安全性好，对母儿影响小。

Propess for Promotion of Cervical Ripening in Full-term Pregnancy

Objective： To explore the efficacy and safety of Propess for induction of cervical ripening and vaginal delivery in term pregnancies. Methods： 120 cases of term pregnancies were randomly divided into experimental group and control group. Propess was inserted in posterior vaginal fornix in 60 cases for 1-2 times, and the control group was treated with microoxytocin. The cervical maturity, time from administration to delivery, stages of labor, rate of vaginal delivery, and side effects of drugs were compared between the two groups. Results：①The increase of Bishop＇s score was 3.81 ± 1.04 in experimental group, significantly higher than 3.09± 1.15 in control group （P〈0.05）. ② The treatment of Propess was more effective in the experimental group than the control group （excellence rate 78.33% vs 35.00%, total effective rate.91.67% vs 63.33%） （P〈0.01）. ③ In experimental group, the rate of vaginal delivery was 73.33%, time from administration to delivery 34.19± 13.20h, time for labor stages 8.47± 2.68h, while in the control group 41.67%, 52.14± 16.05h and 12.25± 3.73h respectively. Difference between the two groups was statistically significant （P〈0.01 or 0.05）.④ The difference of postpartum hemorrhage （225.31± 67.80ml vs 232.44± 75.76ml）, birth weight （3369.48± 311.65g vs 3417.63± 359.68g）, and Apgar＇s scores （9.52± 0.39 vs 9.48± 0.47） was not significant between the experimental group and control group （P〉0.05）. Conclusion： Propess could promote the cervical ripening of term pregnancies, increase the successful rate of vaginal delivery and decrease the cesarean section rate effectively and safely.