Annexin I在PCOS大鼠颗粒细胞中的表达及意义

目的：探讨膜联蛋白I（AnnexinI）在多囊卵巢综合征（PCOS）大鼠卵泡颗粒细胞的表达及生物学意义。方法：采用免疫组织化学方法及灰度值测定AnnexinI在PCOS组和对照组的卵泡颗粒细胞中的表达。结果：AnnexinI在两组中的各级卵泡颗粒细胞中均有表达，PCOS组AnnexinI在窦状卵泡中表达显著高于对照组（P〈0．05）。结论：PCOS组AnnexinI在窦状卵泡颗粒细胞的表达上调，且PCOS中窦状卵泡颗粒细胞的凋亡增加，说明AnnexinI参与了卵巢颗粒细胞的凋亡过程，并且发挥了重要作用。

Expression and Significance ofAnnexin I in Granulosa Cells of Rats with Polycystic Ovarian Syndrome

Objective： To study the expression and biological significance of annexin I in the granulosa cell ofpolycystic ovarian syndrome （PCOS） in rat model. Methods： The expression of annexin I was detected by immunohistochemical method, and the quantitative analysis was performed by the gray value in PCOS and control group. Results： The annexin I expressed in different classes of preantral follicles in both PCOS group and control group. When the diameter of the follicle reached to 60-120um, the annexin I expression had significant difference between the PCOS group and control group （P〈0.05）. Conclusion： The annexin I expression evidently increased in sinusoid follicle and the granulosa cell of apoptosis raised m PCOS group ,which illuminated annexin I paticipated in the process of apoptosis in granulosa cell and played an imrnportant role.