| MPTP/MPP＋诱导神经元凋亡的机制研究 |
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| 引用本文： | 张玉花,蔡蕊,刘江华,朱春雨,解洪荣.MPTP/MPP＋诱导神经元凋亡的机制研究[J].生物磁学,2011(5):964-967. |
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| 作者姓名： | 张玉花 蔡蕊 刘江华 朱春雨 解洪荣 |
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| 作者单位： | [1]大庆油田总医院CT室,黑龙江大庆163001 [2]天津南开华山医院,天津300000 [3]大庆油田总医院神经内科,黑龙江大庆163001 |
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| 摘 要： | 1982年人们发现1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）能诱发PD,它的有效成分是1-甲基-4-苯基吡啶离子（MPP＋）。目前,MPTP/MPP＋广泛的被用作诱导PD实验模型的有效药物,可诱导神经元细胞发生凋亡性死亡。MPTP/MPP＋诱导细胞凋亡的机制牵涉Bcl-2、p53、caspase家族、JNK通路、ERK通路和PARP等多种机制,它们共同参与了MPTP/MPP＋诱导的细胞凋亡的调控和执行阶段。本文主要综述MPTP/MPP＋诱导的神经元细胞凋亡机制。
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| 关 键 词： | 1-甲基-4-苯基-1 2 3 6-四氢吡啶（MPTP） 1-甲基-4-苯基吡啶离子（MPP＋） 帕金森病（PD） 凋亡 |
The study of MPTP/MPP＋-induced apoptosis of neurons |
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| ZHANG Yu-hua,CAI Rui,LIU Jiang-hua,ZHU Chun-yun,XIE Hong-rong.The study of MPTP/MPP＋-induced apoptosis of neurons[J].Biomagnetism,2011(5):964-967. |
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| Authors: | ZHANG Yu-hua CAI Rui LIU Jiang-hua ZHU Chun-yun XIE Hong-rong |
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| Institution: | 1 Department of Computerized Tomography,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China 2 Tianjin nankai huashan hospital,Tianjin city,300000,China;3 Department of Neurology,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China) |
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| Abstract: | Since 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP） and its active neurotoxic metabolite 1-Methy l-4-phe-nyl-pyridinium（MPP＋） have been shown to induce PD,people have done lots of research on the neurotoxicity of MPTP/MPP＋.So,MPTP/MPP＋ has been widely used to be neurotoxin to induce experimental model of PD.MPTP/MPP＋ can induce neuronal apoptosis through various mechanisms,involving Bcl-2,p53,caspase,JNK pathway,ERK pathway and PARP etc.These mechanisms collaborative participate in the control and performance of neuronal apoptosis induced by MPTP/MPP＋.This article mainly review the apoptosis mechanisms induced by MPTP/MPP＋. |
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| Keywords: | 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine（MPTP） 1-methyl-4-phenylpyridinium ion（MPP＋） Apoptosis |
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