可溶性细胞间粘附分子-1在新生儿缺氧缺血性脑病血清中的表达及临床意义

目的：探讨可溶性细胞间粘附分子-1（ICAM-1）在新生儿缺氧缺血性脑病（HIE）血清中的表达及其与病情严重程度的关系。方法：采用酶联免疫吸附双抗体夹心法（ELISA）检测45例HIE新生儿和50例健康新生儿血清中可溶性ICAM-1水平。结果：HIE组血清可溶性ICAM-1浓度为（159．25±25．62）ng／ml，对照组血清可溶性ICAM-1浓度为（53．35±12．42）ng／ml，两组相比较有显著性并差异（P〈0．05）；轻、中、重度HIE患儿血清可溶性ICAM-1浓度与对照组比较显著升高（P〈0．05），在HIE各组中可溶性ICAM-1浓度为重度〉中度〉轻度，各组相比较有显著性差异（P〈0．05）；HIE患儿血清可溶性ICAM-1水平与临床分度呈正相关相关（r=0．652，P〈0．01）。结论：可溶性ICAM-1在HIE新生儿血清中呈高表达，可溶性ICAM-1的水平与病情严重程度密切相关。可溶性ICAM-1在新生儿缺氧缺血性脑损伤中起着重要作用：

Expression and clinical significance of solubility ICAM-1 in newborns with hypoxic ischemic encephalopathy

Objective： To study the expression and clinical significance of solubility ICAM-1 in newborns with hypoxic ischemie encephalopathy（HIE） and the relationship between the severity of the disease. Methods： The serum solubility ICAM-1 level from 45 cases of newborns with HIE （HIE group） and 50 cases of healthy newborns （control group） were detected by enzyme linked immunosorbent assay （ELISA）technology. Results： The serum solubility ICAM-1 level of HIE group was （159.25±25.62）ng/ml, the control group was （53.35 ±12.42）ng/ml, compared the difference was significant （P〈0.05）; The serum solubility ICAM-1 level of Light, moderate and severe group was higher than the control group, compared the difference was significant （P 〈0.05）; The serum solubility ICAM-1 level of HIE group was severe group〉 moderate group 〉 mild group, compared the difference was significant （P 〈0.05）; The serum solubility ICAM-1 level of HIE newborns was positively correlated with the severity of the disease. （r - 0.652, P 〈0.01）. Conclusion： The solubility ICAM-1 has high expression in solubility ICAM-1 in newborns with HIE, The solubility ICAM-1 level is positively correlated with the severity of the HIE disease. The solubility ICAM-1 plays an important role in the process of occurrence and development of hypoxic ischemic brain damage of newborns.