神经节苷脂联合α-硫辛酸治疗糖尿病神经源性膀胱临床观察

目的：观察α-硫辛酸、神经节苷脂联合治疗糖尿病神经源性膀胱的临床疗效。方法：60例2型糖尿病神经源性膀胱患者，随机分为α-硫辛酸治疗对照组、神经节苷脂治疗对照组，联合治疗组，疗程30d，观察症状体征及治疗前后B超膀胱残余尿量症状的变化，比较不同方案的疗效。结果：α-硫辛酸治疗对照组有效率90％，神经节苷脂治疗对照组有效率90％，联合治疗组有效率95％两组间无统计学差异（P〉0．05），但3组的治愈率分别为90．0％、50．0％、60．0%，治疗组的治愈率高于两个对照组，有统计学差异（P〈0．05）。结论：α-硫辛酸和神经节苷脂联合治疗糖尿病神经源性膀胱有较好的临床疗效，值得临床推广。

Clinical Observation on Lipoic acid and Ganglioside in Treating Diabetic Neurogenic Bladder

Objective： The studywas designed to assess the role of lipoic acid and ganglioslde m treating diabetic neurogeme bladder. Methods： Sixty patients with type 2 diabetes and diabetic neurogenic bladder were treated with lipoic acid and ganglioside for 30 days,and the postvoiding residue of bladder measured by ultrasonogram were compared before and after therapy. Results： The postvoiding residue of bladder after therapy were significantly decreased than those before therapy. Comparison of the efficacy of different programs. Results α-lipoic acid treatment control group was 90%, ganglioside treatment control group was 90%, combined treatment group was 95%, there were no significant difference between the two groups （P〉 0.05）, but the 3 groups Cure rates were 90.0%, 50.0%, 60.0% cure rate in treatment group than two control groups, were significantly different （P 〈0.05）. Conclusion： Lipoic acid and ganglioside can significantly improve the postvoiding residue of bladder in patients with diabetic neurogenic bladder which Worthy to be popularized.