| 心脏性猝死者心肌HO-1和VEGF的表达及意义 |
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| 引用本文： | 徐威威,杨彦华,纪萍,韦孝铭,于建宪.心脏性猝死者心肌HO-1和VEGF的表达及意义[J].生物磁学,2011(6):1114-1117. |
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| 作者姓名： | 徐威威 杨彦华 纪萍 韦孝铭 于建宪 |
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| 作者单位： | [1]青岛大学医学院附属市立医院 [2]青岛市市立医院病理科,山东青岛266011 |
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| 摘 要： | 目的：探讨血红素加氧酶-1（heme oxygenase-1,HO-1）、血管内皮生长因子（vascular endothelial growth factor,VEGF）在心脏性猝死病人心室肌细胞中的表达及其意义。方法：运用免疫组织化学方法和Simple PCI图像分析系统观察33例心脏性猝死组和18例非心脏性猝死对照组尸检心肌组织中HO-1、VEGF蛋白的表达情况。结果：心脏性猝死组心肌组织HO-1（155.090±8.957）和VEGF蛋白表达（121.020±10.927）均显著高于非心脏性猝死对照组（116.200±6.355、84.207±4.402,均p〈0.05）。结论：HO-1和VEGF蛋白在心脏性猝死者心肌组织表达增强,可能与心脏性猝死有一定关系。
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| 关 键 词： | 心性猝死 血红素加氧酶-1 血管内皮生长因子 免疫组织化学 |
Expressions of HO-1 and VEGF in Patients of Sudden Cardiac Deathand Their Significances |
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| XU Wei-wei,YANG Yan-hua,JI Ping,WEI Xiao-ming,YU Jian-xian.Expressions of HO-1 and VEGF in Patients of Sudden Cardiac Deathand Their Significances[J].Biomagnetism,2011(6):1114-1117. |
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| Authors: | XU Wei-wei YANG Yan-hua JI Ping WEI Xiao-ming YU Jian-xian |
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| Institution: | 1 The Affiliated Municipal Hospital of Qingdao University MedicalCollege,Qingdao 266021,China;2 Department of Pathology,Qingdao Municipal Hospital,Qingdao 266011,China) |
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| Abstract: | Objective： To investigate expression of the heme oxygenase-1（HO-1）and vascular endothelial growth factor（VEGF） in the left ventricle in patients with sudden cardiac death（SCD）.Methods： Immunohistochemistry and Simple PCI image analysis system were used to detect the expressions of HO-1 and VEGF in 33 cases of SCD and 18 cases of non SCD（control group）.Results： The ex-pressions of HO-1（155.090±8.957） and VEGF（121.020±10.927） in the myocardium of patients in SCD group were significantly higher than those in control group（116.200±6.355,84.207±4.402,all p0.05）.Conclusions： The high expression of HO-1 and VEGF may be related with the sudden cardiac death to some extent. |
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| Keywords: | Sudden cardiac death HO-1 VEGF Immunohistochemistry |
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