| TNF-a在肿瘤中的作用 |
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| 引用本文： | 李涛,陈正望.TNF-a在肿瘤中的作用[J].生物磁学,2011(18):3586-3588. |
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| 作者姓名： | 李涛 陈正望 |
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| 作者单位： | 华中科技大学生命科学与技术学院生物物理所,湖北武汉430074 |
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| 摘 要： | 肿瘤坏死因子是一个特别的，并具有多重功能的细胞因子，它在免疫调节，炎症反应，机体防御当中起着关键的作用。根据不同的细胞微环境，肿瘤坏死因子可以诱导多种反应，例如凋亡，坏死，血管生成，免疫细胞激活，细胞分化，细胞迁移。TNF在肿瘤当中是一把双刃剑。一方面，TNF是一个内源性的肿瘤促进因素，因为TNF可以刺激肿瘤细胞生长，增殖，侵袭，转移，血管生成。另一方面，TNF具有杀肿瘤细胞的作用。因此，如果可以调控肿瘤坏死因子的功能，将为癌症的治疗提供可能。
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| 关 键 词： | 肿瘤坏死因子 肿瘤促进 肿瘤抑制 |
The role of TNF-a in cancer |
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| LI Tao,CHEN Zheng-wang.The role of TNF-a in cancer[J].Biomagnetism,2011(18):3586-3588. |
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| Authors: | LI Tao CHEN Zheng-wang |
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| Institution: | (College of Life Science and Technology, Institute of Biophysics and Biochemistry, Huazhong University of Science and Technology, Wuhan, 430074, China) |
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| Abstract: | Tumor necrosis factor （TNF） is an extraordinarily pleiotropic cytokine with a central role in immune homeostasis, inflammation, and host defense. Dependent on the cellular context, it can induce diverse effects, such as apoptosis, necrosis, angiogenesis, immune cell activation, differentiation, and cell migration. TNF is a double-dealer. On one hand, TNF could be an endogenous tumor promoter, because TNF stimulates cancer cells＇ growth, proliferation, invasion and metastasis, and tumor angiogenesis. On the other hand, TNF could be a cancer killer. Therefore, modulation of the activity of the TNF will offer possibilities for cancer therapy. |
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| Keywords: | TNF-a Tumor promotion Tumor inhibition and treatment |
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