急性冠状动脉综合症患者血浆溶血磷脂酸及基质金属蛋白酶-9水平的检测及意义

目的：探讨急性冠状动脉综合症（acute coronary syndromes，ACS）患者血浆溶血磷脂酸（lysophatidic acid，LPA）及基质金属蛋白酶-9（matrix metalloproteinase-9，MMP．9）水平的变化，探讨其在ACS中可能的临床意义。方法：入选100例ACS患者，根据病情将其分为怠性心肌梗死（AMI）组50例，不稳定型心绞痛（UAP）组50例，并入选40例健康者作为对照组，分别用无机磷定量法和酶联免疫吸附测定法测定血浆LPA、MMP-9水平。结果：AMI组血浆LPA、MMP-9水平显著高于UAP组（LPA：3．29±0．42vs2．67±0．37；MMP-9：481．7±86．5VS237．85±65．34，P〈0．01）并且两组均显著高于对照组（LPA：1．82±0．31；MMP-9：87．42±23．85P〈0．01）；LPA与MMP-9水平呈正相关（r=O．224，P〈0．05）。结论：UIA与MMP-9可能是提示不稳定斑块的形成、破裂，进而导致急性冠状动脉综合征的危险信号。

Detection and Significance of Lysophosphatidic Acid and Matrix Metalloproteinase-9 Levels in Patients with Acute Coronary Syndrome

To investigate the level of plasma lysophosphatidic acid（LPA） and matrix metallopmteinase-9（MMP-9） in patients with acute coronary syndromes（ACS） and to explore the potential clinical significance. Method： A total of 100 patients with ACS were divided into two groups：group AMI（AMI） 50 and group unstable angina （UAP） 50,and 40 healthy persons served as control. Plasma LPA and MMP-9 were determined by inorganic phosphours quantitative method and enzyme-linked iaununosorbent assay. Result： LPA and MMP-9 levels were significantly higher in AMI than in UAP （LPA ：3.29±0.42vs2.67±0.37 ;MMP-9：481.7±86.5 vs 237.85±65.34,P〈0. 01）,and in both group were higher than in controll group （LPA：l.82±0.31; MMP-9：87A2±23.85 P〈0.01）; LPA level was positive correlated with MMP-9 （r=0.224, P〈0.05）. Conclusion： LPA and MMP-9 may serve as a potential risk signal to hint the formation and rupture of unstable atherosclerotic plaque of ACS.