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共轭亚油酸降血脂及抗动脉粥样硬化作用的研究
引用本文:衣丹,林学政,沈继红,刘发义,梁晓芳.共轭亚油酸降血脂及抗动脉粥样硬化作用的研究[J].生物磁学,2011(7):1228-1230.
作者姓名:衣丹  林学政  沈继红  刘发义  梁晓芳
作者单位:[1]国家海洋局第一海洋研究所,山东青岛266061 [2]青岛澳海生物有限公司,山东青岛266101
基金项目:国家高技术研究发展计划"863"资助课题(No.2007AA091905)
摘    要:目的:探讨共轭亚油酸降血脂及抗动脉粥样硬化形成的作用机制。方法:选用大鼠随机分为正常对照组,高脂模型组,c9,t11CLA:t10,c12CLA=2:1、1:1、1:3、1:6,只含t10,c12CLA共7组。实验至第8周末取血,检测血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和丙二醛(MDA)、超氧化物歧化酶(SOD)活性。结果:与高脂模型组比较,共轭亚油酸组大鼠血清TC、TG、MDA含量明显降低,HDL、SOD含量明显提高(P〈0.05)。结论:共轭亚油酸具有降低血脂和抗动脉粥样硬化的作用。

关 键 词:共轭亚油酸  高脂血症  动脉粥样硬化

Effect of Conjugated Linoleic Acid in Lowering Blood Lipids and Anti-atherosclerosis
YI Dan,LIN Xue-zheng,SHEN Ji-hong,LIU Fa-yi,LIANG Xiao-fang.Effect of Conjugated Linoleic Acid in Lowering Blood Lipids and Anti-atherosclerosis[J].Biomagnetism,2011(7):1228-1230.
Authors:YI Dan  LIN Xue-zheng  SHEN Ji-hong  LIU Fa-yi  LIANG Xiao-fang
Institution:1 First Institute of Oceanography,State Oceanic Administration,Qingdao 266061,China; 2 Qingdao Auhai Biotech Co.,Ltd Qingdao 266101,China)
Abstract:Objective:To investigate the mechanism of hyperlipoidemia andanti-atherosclerosis effects by conjugated linoleic acid.Methods:Rats were randomly divided into 7 groups:normal control group,hyperlipidemia model group,c9,t11CLA:t10,c12CLA=2:1,1:1,1:3,1:6,only t10,c12CLA group.8 week after the experiment,the total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),SOD and MDA in sera were detected.Results:Compared with those in the hyperlipi-demia model rats,the levels of MDA and TC,TG in the sera of rats given with CLA were lower(P0.05),while the activity of SOD and level of HDL increased(P0.05).Conclusions:Conjugated linoleic acid could inhibit the hyperlipidemia and prevent the formation of atherosclerosis.
Keywords:Conjugated linoleic acid  Hyperlipoidemia  Atherosclerosis
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