| 胚胎干细胞体外诱导分化 |
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| 引用本文： | 张艳艳,;李林凤,;王颖,;陈莉娜,;靳亚平,;关伟军,;马月辉.胚胎干细胞体外诱导分化[J].生物磁学,2008(6):1169-1171. |
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| 作者姓名： | 张艳艳 ;李林凤 ;王颖 ;陈莉娜 ;靳亚平 ;关伟军 ;马月辉 |
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| 作者单位： | [1]中国农业科学院北京畜牧兽医研究所,北京100094; [2]西北农林科技大学动物医学院,陕西杨凌712100; [3]东北农业大学动物科技学院,黑龙江哈尔滨150030; [4]浙江大学动物科学学院,浙江杭州310029 |
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| 基金项目： | 国家自然科学基金项目（30671539） |
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| 摘 要： | 胚胎干细胞能在体外长期不断自我更新，具有高度分化潜能，可分化成胎儿和成体的几乎所有类型的细胞，如心肌细胞、神经细胞、上皮细胞、肝细胞、血细胞、胰岛细胞、脂肪细胞及生殖细胞等。在细胞治疗和组织器官替代治疗、发育生物学等的研究中将具有广阔的应用前景。目前已有多种胚胎干细胞体外定向诱导的报道。本文从体外诱导分化影响因素和几种主要诱导细胞类型进行分析和总结，为胚胎干细胞的诱导分化研究提供参考资料。
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| 关 键 词： | 胚胎干细胞(ESC) 诱导分化 |
Research Progress on Induced Differentiation of Embryonic Stem Cells in Vitro |
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| Institution: | ZHANG Yah-yah, LI Lin-fen, WANG Yin, CHEN Li- na, JIN Ya-ping, GUAN Wei-jun, MA Yue-hui (1 Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing, 100094; 2 College of Animal Medicine, Northwest Sci-Tech University of Agriculture and Forestry, Yangling, 712100; 3 College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030; 4, College of Animal Science, Zhejian University, Hangzhou,310029, China) |
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| Abstract: | Embryonic stem cell （ESC） could be self-renewal incessantly in long term in vitro. It had high differentiated potentiality and could differentiate into almost every type of cell of foetus and adult. Such as heart muscle cell, nerve cell, epithelia, liver cell, blood corpuscle, islet cell, lipocyte and germ cell, So ESC could be applied widely in cell therapy, tissue and organ replacement therapy, developmental biology and other researches, At present a variety of cell types had be reported that were induced by directed differentiation in vitro. This paper analyzed and summarized infection factors of induced differentiation and several major cell types induced from ESC, and to offer reference for ESC＇s induced differentiation research. |
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| Keywords: | Embryonic stem cell （ESC） Induced differentiation |
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