大肠癌患者血清和组织中sIL-2R和sICAM-1水平的变化及意义

目的：探讨可溶性白细胞介素2受体（sIL-2R）和可溶性细胞间粘附分子1（sICAM-1）的水平在大肠癌患者血清和组织中的变化及临床意义。方法：选择本院于2010年1月-2012年12月收治的55例大肠癌患者作为观察组，选取同期收治的41例大肠息肉患者作为对照组，38例健康志愿者作为健康组，应用双抗体夹心ELISA法对上述三组血清和组织中的sIL-2R和sICAM-1水平进行检测，对比分析上述指标的变化情况及其临床意义。结果：观察组血清和组织中sIL-2R水平分别为（210．3±128．5）pmol／L、（235．8±172．4）pmol／L，明显高于对照组与健康组，比较差异均有统计学意义（P〈0．05），且sICAM-1平均水平为（392．4±133．3）p/μg／L，显著高于对照组和健康组，比较差异亦有统计学意义（P〈0．05）；观察组术后sICAM-2R和sICAM-1水平分别为（85．1±41．7）pmol／L、287.3±106．1（p／ug／L），均显著低于术前，比较差异有统计学意义（P〈0．05）。结论：大肠癌患者机体中sIL-2R及sICAM-1的水平与疾病的发生和存在有密不可分的关系，故临床中，测定两指标的含量对大肠癌的诊断有一定的临床意义，可将其作为一个较为客观的指标进行检测。

Changes and Significance of Serum and Tissue of Patients with Colorectal Cancer in sIL-2R and sICAM-1 Levels

Objective： To investigate the levels of soluble interleukin-2 receptor （sIL-2R） and soluble intercellular adhesion molecule- 1 （sICAM-1） and its clinical significance in patients with colorectal cancer in serum and tissue. Methods： Selected 55 patients with colorectal cancer in my hospital from 2010 January to 2012 Decemberas the observation group,41 cases of colorectal polyps patients as a control group, 38 healthy volunteers as health group, double antibody sandwich ELISA for serum and tissues of the three groups detection of sIL-2R and slCAM-1 levels,comparative analysis and clinical significance of changes in these indicators. Results： The serum and tissues sIL-2R levels were （210.3 ± 128.5） pmol/L, （235.8 ±172.4） pmol/L, significantly higher than the healthy group, the difference was statistically significant（P〈0.05）, and the average level of sICAM-1 （392.4 ± 133.3）p/ug/L, significantly higher than healthy group, there were significant differences（P〈0.05）; observation group after sIL- 2R and slCAM-1 levels were （85.1 ±41.7） pmol/L, 287.3 ±106.1 （p/ug/L）,were significantly lower than before the surgery, the difference was statistically significant （P〈0.05）. Conclusion： The body of patients with colorectal cancer occurred in sIL-2R and slCAM-1 levels with disease and there is a close relationship, so clinical, diagnostic determination of the two indicators for colorectal cancer has clinical significance, can be as a more objective indicator for testing.