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Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells |
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| Authors: | Yuzuru Yamazoe Masanobu Tsubaki Hiroshi Matsuoka Takao Satou Tatsuki Itoh Takashi Kusunoki Yasuhiro Kidera Yoshihiro Tanimori Kaori Shoji Haruyuki Nakamura Mitsuhiko Ogaki Saori Nishiura Shozo Nishida |
| Institution: | a Division of Pharmacotherapy, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan b Department of Pharmacy, Kinki University Hospital, Osaka-Sayama, Osaka 589-8511, Japan c Department of Pharmacy, Nara Hospital, Kinki University School of Medicine, 1248-1 Ikoma, Nara 630-0293, Japan d Department of Pathology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan e Department of Otolaryngology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan f Department of Pharmacy, Higashi-Osaka City General Hospital, Higashi-Osaka 578-8588, Japan |
| Abstract: | NF-κB acts as a signal transducer during tumor progression, cell invasion, and metastasis. Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor-α-induced nuclear entry of NF-κB/p65. However, only a few reports suggest that DMF inhibits tumor metastasis; also the molecular mechanisms underlying the inhibition of metastasis are poorly understood. We investigated the inhibition of tumor invasion and metastasis by DMF in a melanoma cell line, B16BL6. DMF inhibited B16BL6 cell invasion and metastasis by suppressing the expression and activities of MMPs. DMF also inhibited the nuclear entry of NF-κB/p65, thus inhibiting B16BL6 cell invasion and metastasis. These results suggest that DMF is potentially useful as an anti-metastatic agent for the treatment of malignant melanoma. |
| Keywords: | Dimethylfumarate NF-κ B MMP Metastasis Invasion |
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