The significance of combined detection of CysC,urinary mAlb and β2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome |
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| Institution: | 1. Department of Clinical Laboratory, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China;2. Department of Obstetrics and Gynecology, The General Hospital of Western Theater Command, Chengdu 610083, China;3. Child Healthcare Department, Zhucheng Maternal and Child Health Hospital, Zhucheng 262200, China;4. Department of Clinical Laboratory, The First Hospital Affiliated Yunnan University of Traditional Chinese Medicine, Kunming 650021, China;5. Department of Clinical Laboratory, 521 Hospital of Ordnance Industry, Xi’an 710065, China;6. Department of Clinical Laboratory, Jinhua People’s Hospital of Zhejiang Province, Jinhua 321000, China;7. Department of Clinical Laboratory, He Xian Memorial Hospital of Panyu District, Guangzhou 511400, China |
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| Abstract: | ObjectiveTo elaborate the significance of combined detection of cystatin C, urinary micro-albumin (mAlb) and β2-microglobulin (β2-MG) in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome.MethodsA total of 120 patients with pregnancy-induced hypertension syndrome who were admitted to this hospital for treatment between November 2015 and October 2018 were enrolled as subjects, and divided into the control group (without complication of renal injury, n = 76) and the observation group (with complication of renal injury, n = 44) according to the complications of early renal injury. Furthermore, 60 patients who participated in the antenatal care in this hospital were enrolled as the normal subjects (normal group). Automatic biochemistry analyzer was utilized to measure CysC, urinary mAlb and β2-MG in serum to evaluate the specificity, sensitivity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of single or combined measurements of these indexes in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome.ResultsIn the observation group, the levels of CysC, urinary mAlb and β2-MG were higher than those in the control group, while the levels in the normal group were the lowest (P < 0.05). Combined measurement of CysC, urinary mAlb and β2-MG showed a higher accuracy (90.0%) in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome than the single measurements, and the difference had statistical significance (P < 0.05). Besides, the sensitivity, specificity, PPV and NPV of the combined measurements were 94.59%, 87.30%, 81.40% and 94.49%, slightly higher than the single measurements, with no statistical significance in differences (P > 0.05).ConclusionCysC, urinary mAlb and β2-MG can reflect the renal injury effectively, and the combined measurements shows potent accuracy in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome, thereby providing the scientific evidence for early diagnosis and stipulation of rational therapeutic regimen and improving the pregnancy outcome. |
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| Keywords: | Pregnancy-induced hypertension syndrome Early renal injury CysC Urinary mAlb |
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