A study on risk factors for Parkinson?s disease in Indian population |
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| Authors: | Vineeta Gupta Ravindra Kumar Garg Kamlesh Kumar Pant Sanjay Khattri |
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| Institution: | 1.Department of Pharmacology & Therapeutics, King George׳s Medical University, Lucknow-226003, Uttar Pradesh, India;2.Department of Neurology, King George׳s Medical University, Lucknow-226003, Uttar Pradesh, India |
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| Abstract: | Parkinson׳s disease is the second most common neurodegenerative disorder. The exact cause of selective dopaminergic
neurodegeneration is unknown, but it is supposed that etiology of Parkinson׳s disease is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. To find out the association between environmental factors
and risk of Parkinson׳s disease, a case control study was designed including 97 Parkinson׳s disease patients and 97 controls.
Logistic regression analysis was used to determine the risk factors for Parkinson׳s disease. Results from the present study showed
that gender, religion, education, place of living, occupation, dietary habits, tobacco chewing, smoking, alcohol intake, and head
injury had no association with PD. However, chemical exposure and well water drinking were significantly associated with PD,
which concluded that environmental factors could act as a risk factor for PD in some way. |
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| Keywords: | Parkinson׳ s disease risk factors chemical exposure well water |
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