Comparaison de l’IRM de diffusion et de la TEP/TDM au FDG dans le bilan des lymphomes |
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| Authors: | K Bouharati-Moussa D Papathanassiou A Benaissa C Portefaix C Bruna-Muraille A Delmer B Kolb J-C Liehn C Marcus |
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| Institution: | 1. Service de médecine nucléaire, institut Jean-Godinot, 1, avenue du Général-Koenig, BP 171, 51056 Reims cedex, France;2. Faculté de médecine, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51095 Reims cedex, France;3. EA 3804, centre de recherches en sciences et technologies de l’information et de la communication (CReSTIC), université de Reims Champagne-Ardenne, 51687 Reims cedex, France;4. Service de radiologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France;5. Service d’hématologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France;1. Service de médecine nucléaire, CHU Yo Ouadougou, 03 BP, 7022 Ouagadougou 03, Burkina Faso;2. Laboratoire de biophysique, UFR-SDS, université de Ouagadou, 03 BP, 7021 Ouagadougou 03, Burkina Faso;1. Service des explorations externes, institut de cardiologie d’Abidjan, BP V 206, Abidjan, Côte d’Ivoire;2. Laboratoire de physiologie et d’explorations fonctionnelles, UFR sciences médicales d’Abidjan, Abidjan, Côte d’Ivoire;1. Langford Vets, Small Animal Hospital, University of Bristol, Lower Langford, United Kingdom;2. Bristol Vet School, University of Bristol, Lower Langford, United Kingdom;3. Bristol Heart Institute, Bristol Children''s Hospital, Bristol, United Kingdom;1. Service d’imagerie pédiatrique et prénatale, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;2. Département de génétique médicale, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;3. Centre de diagnostic prénatal, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;4. Service de gynécologie obstétrique, hôpital Saint-Joseph, 26, boulevard de Louvain, 13285 Marseille cedex 08, France;5. Service de chirurgie infantile, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;1. Service de médecine nucléaire, hôpital universitaire de Sahloul, route de Ceinture, 4054 Sousse, Tunisie;2. Service de carcinologie médicale, hôpital universitaire de Farhat-Hached, Sousse, Tunisie |
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| Abstract: | PurposeDiffusion weighted MRI (DW-MRI) sequences appear as a promising functional technique supplementary to morphologic MRI for oncology purposes. We evaluated the results of DW-MRI for the staging of lymphomas, compared to FDG PET/CT.MethodsTwenty-seven patients with lymphoma referred for FDG PET/CT (initial staging, relapse or treatment evaluation) were prospectively included. They underwent MRI including free breathing DW and T2 weighted imaging. Lymph node areas and organs involvement were listed for each modality and compared using Cohen's kappa (κ) test. MRI performances were evaluated using FDG PET as the gold standard. The results of PET and MRI were compared (with respect to the final staging by the haematologist).ResultsRegarding the lymph nodes, 154 involved areas were detected by MRI out of the 184 detected by PET, that is an excellent concordance (κ = 0.87), sensitivity of 0.84 and specificity of 1. Concordance and sensitivity were inferior for extranodal disease (notably bone lesions) with 27 lesions detected by MRI out of the 40 viewed with PET. Regarding pre-treatment evaluation, two patients were understaged both with PET and MRI (bone marrow involvement); assessment of stage was concordant for both modalities in 18 patients out of 21.ConclusionsPerformance of MRI including DW images was close to that of FDG PET/CT for lymph node areas involvement. Further studies are needed to assess its sensitivity for extranodal lesions, and its accuracy for determining the stage of the disease. |
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