Imagerie moléculaire nucléaire des paragangliomes |
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| Authors: | D Taïeb L Tessonnier O Mundler |
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| Institution: | 1. York Plasma Institute, Department of Physics, University of York, York YO10 5DQ, United Kingdom;2. EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB, United Kingdom;3. Institut de Radioprotection et de Sûreté Nucléaire, Avenue de la Division Leclerc 31, F-92260 Fontenay-aux-Roses, France;1. CEA, DEN, Centre de Cadarache, F-13108 Saint-Paul-lez-Durance, France;2. CEA, Agence ITER-France, F-13108 Saint-Paul-lez-Durance, France;3. CEA, DEN/DADN, Centre de Saclay, F-91191 Gif-sur-Yvette cedex, France;1. Département d’imagerie, université Pierre-et-Marie-Curie, hôpital Pitié Salpétrière, 47, boulevard de l’Hôpital, 75013 Paris, France;2. Département de médecine nucléaire, institut Pauli-Calmettes, 232, boulevard Sainte-Marguerite, 13273 Marseilles, France;3. Service d’urologie, CHU Mondor, 51, avenue Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France;4. Département d’urologie-andrologie-transplantation rénale, CHU Rangueil, 1, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France;1. York Plasma Institute, Department of Physics, University of York, York YO10 5DQ, United Kingdom;2. UK Atomic Energy Authority, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB, United Kingdom;3. Institut de Radioprotection et de Sûreté Nucléaire, Avenue de la Division Leclerc 31, F-92260 Fontenay-aux-Roses, France;1. IPHC, Université de Strasbourg, Strasbourg, F-67037, France;2. CNRS, UMR7178, Strasbourg, F-67037, France;3. USIAS/Université de Strasbourg, Strasbourg, F-67083, France;4. University of York, York, YO105 DD, UK;5. IPN d’Orsay, UMR8608, CNRS/IN2P3, PSUD 11, Orsay, F-91406, France;6. Department of Physics, University of Surrey, Guildford, GU2 7XH, UK;7. National Physical Laboratory, Teddington, Middlesex, TW110 LW, UK;8. GANIL, CEA/DSM-CNRS/IN2P3, Caen, F-14076, France |
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| Abstract: | Paragangliomas (PGL) are relatively rare neural crest tumors originating in the adrenal medulla (usually called pheochromocytoma), chemoreceptors (i.e., carotid and aortic bodies) or autonomic ganglia. These tumors are highly vascular, usually benign and slow-growing. PGL may occur as sporadic or familial entities, the latter mostly in association with germline mutations of the succinate dehydrogenase (SDH) B, SDHC, SDHD, SDH5, von Hippel-Lindau (VHL), ret proto-oncogene (RET), neurofibromatosis 1 (NF1) (von Recklinghausen's disease), prolyl hydroxylase domain protein 2 (PHD2) genes and TMEM127. Molecular nuclear imaging has a central role in characterization of PGL and include: somatostatine receptor imaging (111In, 68Ga), MIBG scintigraphy (131I, 123I), 18F-dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET), and 18F-deoxyglucose (18F-FDG) PET. The choice of the tracer is not yet fully established but the work-up of familial forms often require the combination of multiple approaches. |
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