Acid proteinase,phospholipase, and biofilm production
of <Emphasis Type="Italic">Candida</Emphasis> species isolated from blood cultures |
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Authors: | Gulce Gokce Nilgun Cerikcioglu Aysegul Yagci |
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Institution: | (1) Department of Clinical Microbiology, Marmara University School of Medicine, Haydarpasa, Istanbul, 81326, Turkey |
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Abstract: | Three virulence factors comprising proteinase, phospholipase, and biofilm among 68 Candida albicans and 31 non-albicans Candida strains (11 C. tropicalis, 8 C. parapsilosis, 6 C. glabrata, 4 C. guillermondii, 2 C. krusei) isolated from blood cultures were analyzed. In total, 61 (89.7%) C. albicans strains were detected as proteinase positive whereas eight (25.8%) non-albicans Candida strains were proteinase positive (P < 0.05). Phospholipase production was detected in 41 (60.3%) C. albicans strains. All non-albicans Candida strains were phospholipase negative. Biofilm production was determined by both visual and spectrophotometric methods. Eight
(11.8%) of C. albicans strains and 13 (41.93%) of 31 non-albicans Candida strains were biofilm positive with two of the methods (P < 0.05). According to our results, we may suggest that detection of hydrolytic enzyme and biofilm production abilities of
the Candida isolates in clinical mycology laboratories may warn the clinican for a possible hematogenous infection. |
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Keywords: | Virulence Candida Blood |
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