Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease |
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| Authors: | M Filali R Lalonde and S Rivest |
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| Institution: | Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Québec;, and Centre Hospitalier de l'Universitéde Montréal/St-Luc, Unitéde Recherche en Sciences Neurologiques, Montréal, Canada;, and Universitéde Rouen, Facultédes Sciences, Rouen, France |
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| Abstract: | Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left–right discrimination learning, concordant with previous findings in other Alzheimer-like models. |
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| Keywords: | Alzheimer's disease APPswe/PS1 depressive-like behavior forced swim test nesting behavior social disinhibition T-water maze |
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