| 内质网区蓖麻毒素的逆向转运 |
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| 引用本文： | 刘琼,詹金彪.内质网区蓖麻毒素的逆向转运[J].细胞生物学杂志,2007,29(4):473-477. |
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| 作者姓名： | 刘琼 詹金彪 |
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| 作者单位： | 宁波大学医学院生物化学与分子生物学研究所 宁波315211(刘琼)，浙江大学医学院生物化学与遗传学系 杭州310058(詹金彪) |
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| 基金项目： | 国家自然科学基金;浙江省自然科学基金 |
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| 摘 要： | 蓖麻毒素是植物来源的核糖体失活蛋白。蓖麻毒素必须通过细胞的内膜系统到达内质网,然后转位至胞质,才能作用于胞质内的核糖体。在内质网中毒素的两条链分离,具有催化活性的A链被内质网上的蛋白质识别,并被转位到胞质内催化核糖体失活。现对内质网在参与蓖麻毒素胞内转运过程中的作用进行综述。
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| 关 键 词： | 蓖麻毒素 内质网 逆向转运 转位 |
| 修稿时间： | 2006-12-25 |
The Retrograde Transport of Ricin around / in Endoplasmic Reticulum |
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| Qiong Liu,Jin-Biao Zhan.The Retrograde Transport of Ricin around / in Endoplasmic Reticulum[J].Chinese Journal of Cell Biology,2007,29(4):473-477. |
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| Authors: | Qiong Liu Jin-Biao Zhan |
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| Institution: | Institute of Biochemistry and Cell Biology, Ningbo University Medical School, Ningbo 315211, China; Department of Biochemistry and Genetics, Zhejiang University Medical School, Hangzhou 310058, China |
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| Abstract: | Ricin is a plant-derived ribosome inactivating protein. To target ribosomes in the mammalian cytosol,ricin must firstly retrograde transport to the endomembrane system of the cell to reach the endoplasmic reticulum. Here,the toxin is reduced and the catalytic A chain is recognised by endoplasmic reticulum components that facilitate its membrane translocation to the cytosol. This review summarises current understanding of these events. |
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| Keywords: | ricin endoplasmic reticulum retrograde transport translocation |
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