| RNA干扰技术治疗疾病 |
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| 引用本文： | 李菁菁,马正海,张富春.RNA干扰技术治疗疾病[J].细胞生物学杂志,2007,29(5):657-660. |
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| 作者姓名： | 李菁菁 马正海 张富春 |
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| 作者单位： | 新疆大学生命科学与技术学院 新疆生物资源基因工程国家重点实验室培育基地，新疆大学生命科学与技术学院，新疆生物资源基因工程国家重点实验室培育基地，新疆大学生命科学与技术学院，新疆生物资源基因工程国家重点实验室培育基地，乌鲁木齐830046，乌鲁木齐830046，乌鲁木齐830046 |
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| 基金项目： | 国家自然科学基金;中国博士后科学基金 |
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| 摘 要： | RNA干扰(RNA interference,RNAi)现象最早发现于秀丽隐杆线虫(Caenorhabditis elegans),随后发现该现象普遍存在于真菌、植物和哺乳动物等真核生物,并行使基因调控和抵御外源基因片段侵袭的作用。目前,RNAi分子机制和RNAi在基因功能方面的研究已经取得了突破性的进展。鉴于RNAi在基因沉默中的特异性、高效性和易操作,其在药物筛选和疾病治疗等方面有着广泛的应用前景。然而,RNAi技术用于治疗疾病的安全性尚待确定,分子传递途径也有待进一步的研究。
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| 关 键 词： | RNA干扰 基因治疗 小干扰RNA |
| 修稿时间： | 2007-02-13 |
RNA Interference Therapy |
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| Jing-Jing Li,Zheng-Hai Ma,Fu-Chun Zhang.RNA Interference Therapy[J].Chinese Journal of Cell Biology,2007,29(5):657-660. |
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| Authors: | Jing-Jing Li Zheng-Hai Ma Fu-Chun Zhang |
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| Institution: | State Key Laboratory Basis of Xinjiang Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumuqi 830046, China |
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| Abstract: | RNA interference (RNAi) was discovered in Caenorhabditis elegans firstly, then it was considered existing widely on eukaryotes (including fungi, plant and mammalian) and playing a role in gene regulation and cellular defense. At present, the breakthrough has achieved in RNAi molecular mechanism and gene function. In view of the sequence-specificity, effectivity and simplicity of the technology, RNAi has widespread application prospect in drug screening and therapy. However, it will be important to assess the safety of the RNAi-based therapies, and the further research on the systemic delivery of the siRNA should be done. |
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| Keywords: | RNA interference therapy small interference RNA |
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