| 基质金属蛋白酶对肿瘤细胞生物学行为调节 |
| |
| 引用本文： | 李秉慧,韩梅,温进坤.基质金属蛋白酶对肿瘤细胞生物学行为调节[J].细胞生物学杂志,2004,26(3):276-280. |
| |
| 作者姓名： | 李秉慧 韩梅 温进坤 |
| |
| 作者单位： | [1]河北医科大学第四医院，石家庄050011 [2]河北医科大学基础医学研究所，河北省医学生物技术重点实验室，石家庄050017 |
| |
| 基金项目： | 河北省自然科学基金(No.C2004000642) |
| |
| 摘 要： | 近年，对于基质金属蛋白酶(matrix metalloproteinases，MMPs)与肿瘤发生发展的关系有了新的诠释，MMPs的功能已不仅限于通过降解细胞外基质来促进肿瘤的侵袭和转移，它们还可通过水解生长因子、黏附分子、受体等非基质蛋白而触发一系列生物学效应，调节肿瘤的生长、分化、凋亡以及肿瘤的血管生成和免疫逃避。重新认识MMPs的功能，将有助于设计以MMPs为靶标的新型抗肿瘤药物。
|
| 关 键 词： | 基质金属蛋白酶 肿瘤 细胞 生物学行为 药物 |
| 文章编号： | 0253-9977(2004)03-276-05 |
| 修稿时间： | 2003年10月8日 |
Matrix Metalloproteinases in Cancer Progression |
| |
| LI Bing Hui,HAN Mei,WEN Jin Kun The Fourth Hospital,Hebei Medical University,Shijiazhuang ,China Institute of Basic Medical Science,Hebei Medical University,Shijiazhuang ,China.Matrix Metalloproteinases in Cancer Progression[J].Chinese Journal of Cell Biology,2004,26(3):276-280. |
| |
| Authors: | LI Bing Hui HAN Mei WEN Jin Kun The Fourth Hospital Hebei Medical University Shijiazhuang China Institute of Basic Medical Science Hebei Medical University Shijiazhuang China |
| |
| Institution: | LI Bing Hui,HAN Mei,WEN Jin Kun The Fourth Hospital,Hebei Medical University,Shijiazhuang 050011,China Institute of Basic Medical Science,Hebei Medical University,Shijiazhuang 050017,China |
| |
| Abstract: | In addition to the extracellular, the matrix metalloproteinases (MMPs) have been found recently to
process a wide variety of nonmatrix substrates. MMPs are important in the cleavage of a number of growth
factors, receptors, angiogenic stimulators and factors that can modulate cellular migration. The cleavage of the
nonmatrix substrates by MMPs affects cellular signaling and functions, regulates various cell behaviors with rel-
evance for cancer biology. To better target MMPs for cancer treatment, an appreciation of their many functions is
needed. |
| |
| Keywords: | matrix metalloproteinases nonmatrix proteins cancer cell behaviors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
