| 蛋白质组学在神经退行性疾病中的研究进展 |
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| 引用本文： | 何胜祥,陈平,郭占云,邵晓霞.蛋白质组学在神经退行性疾病中的研究进展[J].细胞生物学杂志,2007,29(2):173-178. |
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| 作者姓名： | 何胜祥 陈平 郭占云 邵晓霞 |
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| 作者单位： | 同济大学生命科学与技术学院蛋白质研究所 上海200092 |
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| 摘 要： | 蛋白质组学是后基因组时代兴起的新型学科,是从整体水平对蛋白质的综合分析。阿尔茨海默病、帕金森病、肌萎缩侧索硬化症等是最常见的神经退行性疾病。应用蛋白质组学对它们进行研究,不仅可从蛋白质水平上揭示疾病的本质,还有助于全面探讨其病理机制,建立诊断标准,发现药物治疗靶点。
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| 关 键 词： | 蛋白质组学 阿尔茨海默病 帕金森病 肌萎缩侧索硬化症 |
| 修稿时间： | 2006-09-20 |
The Progress in Proteomics Researches of Neurodegeneration Disorders |
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| Sheng-Xiang He,Ping Chen,Zhan-Yun Guo,Xiao-Xia Shao.The Progress in Proteomics Researches of Neurodegeneration Disorders[J].Chinese Journal of Cell Biology,2007,29(2):173-178. |
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| Authors: | Sheng-Xiang He Ping Chen Zhan-Yun Guo Xiao-Xia Shao |
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| Institution: | Institue of Protein Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China |
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| Abstract: | Proteomics, an emerging discipline in the post-genomic era, is the integrated studies of protein properties on a large scale. Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) are the most common neurodegeneration disorders. Using the proteomic approaches, it is possible to eluci-date the nature of these diseases at protein level. It is also helpful to understand their pathological mechanisms, and to diagnose and cure these diseases. |
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| Keywords: | proteomics Alzheimer's disease Parkinson's disease amyotrophic lateral sclerosis |
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