| 小鼠骨髓造血干细胞、外周血组成随年龄的变化趋势及其相关性分析 |
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| 引用本文： | 赵凯,杨星宇,万颖寒,孙瑞林,费俭.小鼠骨髓造血干细胞、外周血组成随年龄的变化趋势及其相关性分析[J].细胞生物学杂志,2011(11). |
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| 作者姓名： | 赵凯 杨星宇 万颖寒 孙瑞林 费俭 |
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| 作者单位： | 同济大学生命科学与技术学院;上海南方模式生物研究中心; |
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| 基金项目： | 科技部重大专项(No.2010CB945501)资助项目~~ |
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| 摘 要： | 造血干细胞是具有自我更新能力并能分化为血液中各种血细胞组分的多能干细胞。近来研究显示,不同造血干细胞表面标志物标记的造血干细胞具有分化为不同血细胞的趋势,但是这种分化的内在关系仍不清楚。对小鼠CD34~-/Sca-1~+骨髓造血干细胞、外周血组成随小鼠年龄增长的变化情况进行了分析,结果显示:随着年龄的增长,骨髓中的CD34~-/Sca-1~+骨髓造血干细胞比率显著增加;而外周血各组分则随年龄变化呈现不同的趋势。对不同年龄段小鼠的骨髓造血干细胞及其他组分与外周血组分的同步分析发现,外周血中血小板密度变化趋势与CD34~-/Sca-1~+骨髓造血干细胞变化情况相关系数为0.804 8;外周血中淋巴细胞密度变化趋势与CD34~+/Sca-1~-骨髓细胞的变化情况相关系数为0.947 97;外周血中白细胞密度变化趋势与CD34~+/Sca-1~+骨髓细胞变化情况相关系数为0.763 1(大于0.9为极度相关,0.7到0.9为高度相关)。
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| 关 键 词： | 骨髓造血干细胞 外周血 相关性 |
Age-related Study on Mice Bone Marrow Stem Cell and Peripheral Blood Composition as well as Their Correlation |
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| Zhao Kai,Yang Xingyu,Wan Yinghan,Sun Ruilin,Fei Jian.Age-related Study on Mice Bone Marrow Stem Cell and Peripheral Blood Composition as well as Their Correlation[J].Chinese Journal of Cell Biology,2011(11). |
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| Authors: | Zhao Kai Yang Xingyu Wan Yinghan Sun Ruilin Fei Jian |
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| Institution: | Zhao Kai~1,Yang Xingyu~1,Wan Yinghan~2,Sun Ruilin~(2*),Fei Jian~(1,2) (1 School of Life Science and Technology,Tongji University,Shanghai 200092,China,2 Shanghai Research Center for Model Organisms,Shanghai 201203,China) |
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| Abstract: | Peripheral blood cells are known to be derived from a self renewing population of hematopoietic stem cells residing in the bone marrow,but the relation between hematopoietic stem cells and the cells of peripheral blood is rarely understood.We explore the changes of CD34~-/Sca-l~+hematopoietic stem cell population in bone marrow and peripheral blood composition of C57BL/6J mouse during aging.The CD34~-/Sca-1~+cell population in bone marrow is increasing during the aging.We also study on the tendency of diffe... |
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| Keywords: | bone marrow hematopoietic stem cell peripheral blood correlation |
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