磷脂酰肌醇转移蛋白

磷脂酰肌醇转移蛋白(phosphatidylinositol/phosphatidylcholine transfer proteins,PITP)普遍存在于真核生物细胞中,PITP能够结合并交换一分子的磷脂酰肌醇(phosphatidylinositol,PI)或磷脂酰胆碱(phosphatidylcholine,PC),并促进这两类脂分子在细胞内膜组分间的转移。PITP对细胞内膜组分间脂类的运输和代谢、分泌囊泡的形成和运输、磷脂酶C(phospholipase,PLC)调节的信号传导以及神经退化等生理生化过程具有重要的影响。综述了近年来PITP的研究进展,并对目前研究中存在的一些问题进行探讨。

Phosphatidylinositol/Phosphatidylcholine Transfer Proteins

Phosphatidylinositide/phosphatidylcholine transfer proteins (PITP) are ubiquitous proteins in all eukaryotic cells, such as metazoans, fungi and higher plants. PITP binds and exchanges one molecule of either phosphatidylinositide or phosphatidylcholine and facilitates the transfer of these lipids between different membrane compartments in vitro. PITP regulate secretory vesicles formation, trafficking, cell budding and PLC-mediated signaling and neurological degradation in metazoans; lipid metabolism and membrane trafficking in yeast; signaling in plant development. Herein, we review recent advances in PITP in biological and cellular levels and the intriguing mechanisms by which PITP execute their functions are still unknown.