猪多能干细胞的研究进展

多能干细胞，如胚胎干细胞（embryonic stem cells，ESCs）、诱导多能干细胞（induced pluripotent stem cells，iPSCs）和成体干细胞（adultstemcells，ASCs），是一类具有巨大潜能的独特细胞。猪作为试验材料，在遗传、代谢、生理生化及基因序列等方面较小鼠更接近于人类，正逐渐成为人类异种移植和再生医学研究的理想生物学模型。然而，目前对猪多能干细胞种类、来源、特征及机制的有限认识直接阻碍了其相关应用。该文将分别对猪ASCs的研究现状、猪类ESCs的分离培养、猪iPSCs的研究进展、多能干细胞间的联系和展望进行论述，以期为从事该领域研究的科研人员提供参考。

Recent Progress of Porcine Pluripotent Stem Cells

Pluripotent stem cells, such as embryonic stem cells, induced pluripotent stem cells and adult stem cells, are unique cells with great value. Pigs are considered as a kind of more ideal biomedical model in human xenotransplantation and regenerative medicine, bearing similar properties with human in genetic, metabolism, physiology, biochemistry and gene sequence. However, limited information on the sorting, derivation, characteriza- tion and mechanisms of porcine pluripotent stem cells impairs their application. Herein, we briefly reviewed the lat- est progresses about the derivation, current status, interrelationships and future perspectives of porcine pluripotent stem cells, in order to providing a useful reference for researchers＇ working in this filed.