Galectin-7与MMP-9在食管鳞状细胞癌中的表达与术后早期复发转移的关系

通过免疫组织化学法检测半乳糖凝集素-7（Galectin-7）与基质金属酶-9（matrix metalloproteinase-9,MMP-9）在食管鳞癌（esophageal squamous cell carcinoma,ESCC）组织和癌旁组织中的蛋白表达,分析其表达与食管鳞癌的临床病理参数及早期复发转移（≤1年）的关系。结果显示,Galectin-7和MMP-9在食管鳞癌组织中的阳性表达率增高。Galectin-7和MMP-9蛋白表达与TNM分期、浸润深度以及淋巴结转移密切相关,二者表达呈正相关。联合检测MMP-9和Galectin-7对于预测术后早期的复发转移的灵敏度、特异度高于单独检测Galectin-7和MMP-9。Galectin-7和MMP-9在食管鳞癌的发生发展过程中可能起着重要的协同作用,联合检测二者可为预测食管鳞癌的复发转移提供帮助。

Expression of Galectin-7 and MMP-9 in Esophageal Squamous Cell Carcinoma and It＇s Relationship with Early Postoperative Recurrence

Examined the expressions of Galectin-7 and MMP-9 in esophageal squamous cell carcinoma （n=50） and noncencerous specimens （n=38） by immunohistochemistry to analyze the relationship between the expressions of Galectin-7, MMP-9 and the clinicopathological features. The expressions of Galectin-7 and MMP-9 were increased in esophageal squamous cell carcinoma （ESCC）. The expressions of Galectin-7 and MMP-9 were correlated with TNM stages, invasive depths and lymph node metastasis. Positive correlation between Galectin-7 and MMP-9 were found in ESCC. For prognosis of early recurrence and metastasis, the specificity and sensitivity of combined detection of Galectin-7 and MMP-9 were both higher than detecting Galectin-7 or MMP-9 alone. Galec- tin-7 and MMP-9 might play an important role in the pathogenesis and progress of ESCC. Combined detection of Galectin-7 and MMP-9 could be helpful for prognosis of early recurrence and metastasis in ESCC.