Na+K+-ATP酶抑制引起的细胞凋亡和杂合性细胞死亡

Na^ -K^ -ATP酶也称Na^ 泵或Na^ -K^ 泵，是哺乳类细胞膜进行离子转运的跨膜载体蛋白。其基本作用是维持细胞膜内外Na^ -K^ 电化学梯度的平衡。近来研究表明，Na^ -K^ -ATP酶在细胞死亡中起重要作用，细胞K 缺失导致凋亡，在某些类型的细胞中，同一细胞兼具细胞肿胀、细胞器溶解等坏死特征和染色质凝集、DNA梯带、caspase级联反应等凋亡特征，呈现一种特殊的细胞死亡形式，即杂合性细胞死亡。

The Apoptosis and Hybrid Cell Death Induced by the Na+-K+-ATPase Blocking

The Na -K -ATPase, sometimes called Na pump or Na -K pump, is a transmembrane enzyme acting as an electrogenic ion transporter in the plasma membrane of all mammalian cells. The primary role of the Na -K -ATPase is to maintain high intracellular K and low intracellular Na . More importantly, accumulating evidence now endorses a close relationship between cellular K depletion and apoptosis. In some cell types, cellular K depletion induces a newly recognized "hybrid cell death" of concurrent apoptosis and necrosis in the same cells.