| 线粒体电压依赖性阴离子通道及其调控功能 |
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| 引用本文： | 汤新慧,高静,徐强.线粒体电压依赖性阴离子通道及其调控功能[J].细胞生物学杂志,2005,27(2):113-116. |
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| 作者姓名： | 汤新慧 高静 徐强 |
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| 作者单位： | [1]南京大学医学院药物研究所，南京210093／／盐城师范学院生物系，盐城224002 [2]南京大学医学院药物研究所，南京210093 [3]南京大学生命科学学院医药生物技术国家重点实验室，南京210093 |
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| 摘 要： | 电压依赖性阴离子通道(voltage-dependent anion channel，VDAC)是存在于线粒体外膜上的31kDa膜蛋白，能在膜上形成亲水性通道，调控阴离子、阳离子、ATP以及其他代谢物进出线粒体，在调节细胞代谢、维持胞内钙稳态，调节细胞凋亡和坏死等过程中发挥重要功能。现就VDAC的结构、特性、活性调节及对细胞功能的调控作一综述。
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| 关 键 词： | 线粒体 电压依赖性阴离子通道 调控功能 结构 活性调节 钙稳态 细胞凋亡 |
| 修稿时间： | 2004年7月30日 |
Mitochondrial VDAC and Its Modulation |
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| Xin-Hui Tang,Jing Gao,Qiang Xu.Mitochondrial VDAC and Its Modulation[J].Chinese Journal of Cell Biology,2005,27(2):113-116. |
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| Authors: | Xin-Hui Tang Jing Gao Qiang Xu |
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| Institution: | Xin-Hui Tang1,2,Jing Gao1*,Qiang Xu3 |
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| Abstract: | Voltage-dependant anion channel (VDAC), a 31 kDa membrane protein, forms an aqueous channel in the mitochondrial outer membrane. As a protein providing the pathway for transporting anions, cations, ATP and other metabolites into and out of the mitochondria, VDAC plays very important roles in not only the regulation of mitochondrial basic physiological function such as energy transduction, substance metabolism, intracellular calcium homeostasis but cell death. This paper summarizes the recent advances in the research on the structure, characterization, and the regulation of VDAC channel and reviews the physiological relevance of VDAC to calcium homeostasis and mitochondria-mediated necrosis and apoptosis. |
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| Keywords: | mitochondria voltage-dependant anion channel calcium homeostasis necrosis and apoptosis |
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