| Wnt信号通路:调控机理和生物学意义 |
| |
| 引用本文： | 尹定子,宋海云.Wnt信号通路:调控机理和生物学意义[J].细胞生物学杂志,2011(2). |
| |
| 作者姓名： | 尹定子 宋海云 |
| |
| 作者单位： | 中国科学院系统生物学重点实验室; |
| |
| 基金项目： | 中国科学院百人计划(No.2010OHTP12); 973计划(No.2011CB943900)资助项目~~ |
| |
| 摘 要： | Wnt信号通路作为一种在进化中高度保守的信号通路,在生长、发育、代谢和干细胞维持等多种生物学过程中发挥重要作用。而Wnt通路的失控与癌症、肥胖和糖尿病等疾病的发生有密切联系。经典Wnt通路的调控过程,主要围绕beta-Catenin和TCF这两个关键调节因子进行,从而在转录水平上影响着大量与生长和代谢相关的靶基因的表达。本文将综合介绍近年来针对经典Wnt通路调控机理的研究进展,以及Wnt通路与疾病发生的关系。
|
| 关 键 词： | Wnt beta-Catenin TCF 发育 疾病 |
Regulation of Wnt Signaling:Mechanisms and Biological Significance |
| |
| Ding-Zi Yin,Hai-Yun Song.Regulation of Wnt Signaling:Mechanisms and Biological Significance[J].Chinese Journal of Cell Biology,2011(2). |
| |
| Authors: | Ding-Zi Yin Hai-Yun Song |
| |
| Institution: | Ding-Zi Yin,Hai-Yun Song~* (Key Laboratory of Systems Biology,Chinese Academy of Sciences,Shanghai 200031,China) |
| |
| Abstract: | The Wnt signaling pathway is highly conserved during evolution,and plays important roles in animal growth,development,metabolism,and maintenance of stem cells.Misregulation of Wnt signaling contributes to human diseases including cancer,obesity and diabetes.Beta-Catenin and TCF are key regulators in the canonical Wnt pathway,controlling expression of genes involved in growth and metabolism.Here we will discuss the progress in the study of mechanisms that regulate the canonical Wnt pathway,and the implicatio... |
| |
| Keywords: | Wnt beta-Catenin TCF development disease |
| 本文献已被 CNKI 等数据库收录！ |
|
