成体干细胞Niche与肺脏修复

肺脏是个开放的复杂器官,覆盖其表面的上皮细胞持续暴露在病原微生物和大气污染物中,最易受到损伤,因而关于它的结构和功能修复问题一直是研究的热点。成体干细胞具有多向分化潜能,在不同niche的作用下可以分化成不同的细胞。肺脏的不同区域含有不同的干细胞,而且这些上皮干细胞在某些特定的条件下可以产生增殖和转分化,因而这些不同水平的干细胞可以通过不同的修复方式来实施肺脏结构和功能的维持和修复,但这些干细胞的来源及其在肺脏修复中的作用和机制并不十分清楚。因此对肺脏成体干细胞的研究进展进行综述以期对肺脏的修复有一个新的认识。

Adult Stem Cell Niche and Lung Repair

Lung is an opening complex organ, of which the epithelia is easily injuried by pathogenic microorganism and atmospheric pollutants resulting from continuously exposure to them. So the topic about its repairment in structure and function is still a hot spot in research. Adult stem cells have multi-directional differen- tiation potency, which can differentiated into different cells within different niche. Different region of lung has different stem cells, which have proliferation and transdifferentiation under some conditioned situation. So the repairment of lung in structure and function can be achieved by these stem cells in different level and their own repairing method. Now some aspects of these stem cells about its source, its effect and mechanism in lung repair are still unclear, so this article reviews some related progresses in order to provide a new recognition of lung repair.