葡萄球菌毒力调控中的群体感应系统

葡萄球菌细胞密度依赖性的多基因表达调控(群体感应)系统,是通过自身诱导与信号转导途径使其感知环境信息,调节多种毒力因子的表达。这些毒力因子的表达受agr、sae以及arl等多种基因表达系统的紧密调控,同时也受Sar家族蛋白的调节。此外,葡萄球菌毒力及抗性密切相关的生物膜形成与发育,也受群体感应系统的影响。对群体感应系统的自身诱导作用的干扰,原则上可成为寻找新型抗菌药物较适合的途径。

Quorum Sensing System in the Regulation of Staphylococcal Virulence

Cell-density-dependent multi-gene regulation system (quorum sensing) in bacteria enables staphylococcal cells to sense the environmental information and regulate the expression of numerous virulence factors via the autoinduction and signal transduction pathway. Expression of these virulence factors is tightly con-trolled by numerous regulatory loci such as agr, sae, and arl etc, as well as by proteins with homology to Sar family. In addition, quorum sensing is required for the formation and development of biofilm which is close related to the staphylococcal virulence and drug resistance. Targeting to disrupt the autoinduction of quorum sensing systems might in principle constitute a reasonable way to find novel antibacterial drugs.