| LZ—410盼生安对肝癌细胞细胞周期时相的影响及对DNA损伤效应的观察 |
| |
| 引用本文： | 李煜,杨素霞,樊飞跃,曹珍山,周淑珍,涂开成,刘国廉.LZ—410盼生安对肝癌细胞细胞周期时相的影响及对DNA损伤效应的观察[J].细胞生物学杂志,1996(4). |
| |
| 作者姓名： | 李煜 杨素霞 樊飞跃 曹珍山 周淑珍 涂开成 刘国廉 |
| |
| 作者单位： | 北京放射医学研究所 100850
(李煜，杨素霞，樊飞跃，曹珍山，周淑珍，涂开成)，北京放射医学研究所 100850(刘国廉) |
| |
| 摘 要： | LZ-410盼生安是一种广谱抗肿瘤药物。本文以5-Fu作为阳性对照药物从对BEL-7402肝癌细胞周期时相的影响及对DNA损伤效应两个方面进行了初步探讨。结果表明,LZ-410能将细胞阻滞在G0/G1期,抑制了细胞的生长增殖作用。并且在本实验条件下,LZ-410并不引起DNA的损伤。这表明LZ-410抑制肝癌细胞生长增殖不是通过对DNA损伤引起的,而主要是通过阻滞肿瘤细胞于G0/G1期实现的。
|
| 关 键 词： | LZ-410盼生安 5-Fu 细胞周期 DNA损伤 |
THE EFFECT OF LZ-410 PANSHENGAN ON CELL CYCLE PHASE AND DNA DAMAGE IN HEPATOMER CELLS |
| |
| LI Yu et al.THE EFFECT OF LZ-410 PANSHENGAN ON CELL CYCLE PHASE AND DNA DAMAGE IN HEPATOMER CELLS[J].Chinese Journal of Cell Biology,1996(4). |
| |
| Authors: | LI Yu |
| |
| Abstract: | LZ-410 panshengan is a kind of wide spectrum anti-tumor drug. The effect on cell cycle phase and DNA damage in BEL-7402 hepatomer cell line was preliminarily studied using 5-Fu as positive control. The results showed that LZ-410 could detain the cells at G0/G1 phase. So it could rcsist cell prolil'eration. The results also showed that LZ-410 couldn't induce DNA damage under this expcnmental conditions. This indicated that LZ-410 resisted cell growth not by DNA damage, but by detaining cells in G0/G1 phase. |
| |
| Keywords: | LZ-410 panshengan 5-Fu Cell cycle DNA damage |
| 本文献已被 CNKI 等数据库收录！ |
