热休克蛋白对细胞凋亡的调控作用

热休克蛋白属于细胞内分子伴侣蛋白，除涉及细胞内一些蛋白质分子构象和稳定性的调节之外，热休克蛋白对细胞应激、代谢、增殖以及凋亡等生理过程均具有重要的调控作用。研究表明热休克蛋白对细胞凋亡的调控机制是复杂的，可直接作用于与凋亡相关的蛋白质，也可以通过影响细胞信号传递而间接影响凋亡的发生。由于热休克蛋白对细胞凋亡的调控机制大多依赖于其分子伴侣功能，阻断热休克蛋白的伴侣功能已经成为研究药物诱导肿瘤细胞凋亡的重要靶点。

Regulation of Cell Apoptosis by Heat Shock Proteins

Heat shock proteins (HSPs) were ubiquitous molecular chaperone proteins that were involved inthe regulation of various physiological processes such as stress response, metabolism, proliferation and apoptosis.The mechanism of how HSP protect the cells from apoptosis was complicated, as HSP could either regulate thestructure and function of several key apoptotic mediators or affect multiple apoptotic signaling pathways. Becausethe modulation of HSP on apoptosis depends on their capacity as chaperon proteins, blockage the chaperoningfunction of HSP90 has become a potential target for inducing apoptosis by anticancer drugs.