AGR2：一个新的癌症诊断标记

AGR2（anterior gradient．2）是一种分泌蛋白，广泛存在于前列腺、乳腺、肺和胰腺等腺体组织，并在这些腺体的肿瘤组织过量表达，与肿瘤细胞的存活、生长和转移相关。临床上，AGR2的表达与乳腺癌、前列腺癌、胰腺癌等癌症的发展和预后相关，被认为是一个很有前途的早期诊断和判定预后的标志性基因。该文就目前AGR2的研究现状，尤其是肿瘤相关的功能、机制和临床调查上的最新研究进展加以综述。

AGR2： A New Biomarker of Cancer Diagnosis

AGR2 is a secreted protein and widely found in the prostate, breast, lung and pancreatic gland tissue. It has excessive expression in the tumor tissue of these glands and regulates tumor cell survival, growth and metastasis. Clinical expression of AGR2 in breast cancer, prostate cancer and pancreatic cancer is relative to the progress of tumor development. Thus, AGR2 is considered to be a promising biomarker for early diagnosis and prognosis, in this paper, we reviewed the current research status of AGR2, especially tumor related functions, clinical investigation and mechanisms.