低剂量混合污染生态毒理与风险评价研究进展

环境中的化学品往往以低剂量混合形式存在.对单一化学品高剂量暴露下的生态毒性研究成果，难以适用于环境中低剂量混合物的生态毒理效应诊断及风险评价.文中概述了低剂量化学品混合污染生态毒理及风险评价方面的研究进展，主要包括低剂量化学品混合污染诊断的分子毒理研究方法、风险评价方法，并介绍了简单和复杂混合物的风险评价方案.对低剂量混合污染生态毒理与风险评价研究的发展动向提出了见解,指出低剂量化学混合物的研究需要寻找敏感终点，引入多学科手段，积累更多的数据，建立完善、统一的评价体系.

Research advances in ecotoxicology and risk assessment of chemical mixtures at low doses

Chemicals in the environment often exist as mixtures and at low doses, whose ecotoxicological diagnosis and risk assessment are hard to be done with the help of the research results on the ecotoxicity of high-level exposure of single chemicals. This paper reviewed the research advances in ecotoxicology and risk assessment of low-dose chemical mixture contamination, with the focus on the molecular toxicological methods and the risk assessment approaches and schemes of simple and complex mixtures. Comments were given on the development directions of low-dose chemical mixture research, including the necessity of searching for sensitive endpoints, involving the approaches of other disciplines, increasing data accumulation, and setting up a comprehensive and identical risk assessment system.