阿苯哒唑对蚯蚓的生态毒理效应

采用人工污染土壤法测定了不同浓度阿苯哒唑对蚯蚓生长、生存、繁殖以及超氧化物歧化酶（SOD）、谷胱甘肽-硫转移酶（GST-S）、乙酰胆碱酯酶（AchE）活性的影响.结果表明:低浓度阿苯哒唑（5 mg·kg^-1）对蚯蚓的繁殖有显著的抑制作用（P<0.05）；当阿苯哒唑含量达到7 mg·kg^-1时，将明显影响蚯蚓的生长和生存（P<0.05）;当其含量达到10 mg·kg^-1时,蚯蚓的死亡率为53%.阿苯哒唑浓度与蚯蚓的生长、繁殖间存在明显的剂-效关系.阿苯哒唑染毒21 d后,对蚯蚓SOD、GST-S的活性有明显影响,药物浓度与效应间没有明显的剂-效关系，对AchE活性没有表现出明显的影响.阿苯哒唑对土壤动物显示毒性作用,具有潜在的生态风险.

Ecotoxicolgical effects of albendazole on Eisenia fetida

By using artificial soil test,the effects of different concentration albendozole on Eisenia foetida's growth,survival,reproduction,and activities of superoxide dismutase(SOD),glutathione-sulfurtransferase(GST-S)and acetylcholine esterase(AchE)were studied.Low concentration (5 mg·kg~(-1))albendazole inhibited the reproduction of E.foetida significantly(P<0.05),and 7 mg·kg~(-1) of albendazole had significant effects on the growth and survival of E.foetida.When the albendazole concentration reached to 10 mg·kg~(-1),the mortality of E.foetida was as high as 53%.There was a significant dose-response relationship between the exposure concentration of albendazole and the inhibition rate of E.foetida's growth and reproduction.After 21 days'albendazole exposure,the SOD and GST-S activities were affected significantly,but no significant doseresponse relationship was observed.Albendazole exposure had less effects on AchE activity.In sum,albendazole had direct toxicity on soil animals,with a potential ecological risk.