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Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome
Authors:Emma J Chory  Joseph P Calarco  Nathaniel A Hathaway  Oliver Bell  Dana S Neel  Gerald R Crabtree
Institution:1. Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA;2. Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA;3. Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA;4. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), 1030 Vienna, Austria;5. Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089-9601, USA;6. Howard Hughes Medical Institute, Chevy Chase, MD, USA
Abstract:
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  • Keywords:DOT1L/KMT4  histone methyltransferase  nucleosome turnover  histone demethylation  mixed lineage leukemia  epigenome modeling
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