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Type III-A CRISPR-Cas Csm Complexes: Assembly,Periodic RNA Cleavage,DNase Activity Regulation,and Autoimmunity |
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| Authors: | Ning Jia Charlie Y Mo Chongyuan Wang Edward T Eng Luciano A Marraffini Dinshaw J Patel |
| Institution: | 1. Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Southern University of Science and Technology, Shenzhen, Guangdong 518055, China;3. Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA;4. Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA |
| Abstract: |  |
| Keywords: | cryo-EM type III-A CRISPR-Cas complexes ternary complex assembly with crRNA and target RNA 5′ repeat tag pairing controls autoimmunity RNA cleavage with 6-nt periodicity DNase activity regulation by Glu residues |
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