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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
Institution:1. Department of Biology, McGill University, Montreal, QC, Canada;2. Institute of Neuropathology, University Hospital Münster, Münster, Germany;3. Department of Human Genetics, McGill University, Montreal, QC, Canada;4. Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon;5. Department of Genetics and Development, Columbia University, New York, NY, USA;6. The Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada;7. Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands;8. Department of Paediatrics, McGill University and the Research Institute of the McGill University Health Center, Montreal, QC, Canada
Abstract:
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Keywords:oncohistones  Drosophila  K27M  K36M  H3K27me3  H3K36me2  transposons  piRNA  krimp  ash1
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