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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

Authors:	Weizhi Liu Kyle M Draheim Rong Zhang David A Calderwood Titus J Boggon

Institution:	1. Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA;2. Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA;3. Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA

Abstract:	Download : Download high-res image (110KB) Download : Download full-size image Highlights? Cocrystal structure of KRIT1 with ICAP1 shows a bidentate interaction interface ? Cocrystal structure of ICAP1 with integrin β1 shows a PTB-peptide interaction ? KRIT1 antagonizes ICAP1-modulated integrin activation by the bidentate interaction ? KRIT1 contains a previously undescribed N-terminal Nudix domain

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