Dracaenogenins A and B, new spirostanols from the red resin of Dracaena cochinchinensis |
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| Authors: | Zheng Qing-An Li Hai-Zhou Zhang Ying-Jun Yang Chong-Ren |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. |
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| Abstract: | A 12(13-->14)abeospirostanol dracaenogenin A (1) and a spirostanol dracaenogenin B (2) were isolated from Chinese dragon's blood, the red resin of Dracaena cochinchinensis (Agavaceae). Their structures were established as (14S,25R)12(13-->14)abeospirosta-5,13(18)-diene-1beta,3beta,15alpha-triol (1) and (25R) spirost-5-ene-1beta,3beta,14alpha,15alpha-tetrol (2) by means of spectroscopic analysis, especially by 2D NMR spectra, and X-ray crystallographic analysis. Dracaenogenin A (1) is the first example of a 12(13-->14)abeospirostane spirostanoid found in nature. Its biogenesis from ruscogenin (3) through namogenin (4) and 2 was tentatively proposed. |
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| Keywords: | Dracaena cochinchinensis Agavaceae Dracaenogenins A and B 12(13→14)Abeospirostane Spirostanol X-ray |
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