Identification of the sugars involved in mycobacterial cell aggregation |
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Authors: | Véronique Anton Pierre Rougé Mamadou Daffé |
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Institution: | Institut de Pharmacologie et de Biologie Structurale du Centre National de la Recherche Scientifique, 205 route de Narbonne, 31077 Toulouse Cedex France; UniversitéPaul Sabatier, 118 route de Narbonne, 31077 Toulouse Cedex France |
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Abstract: | Abstract Incubation of Mycobacterium tuberculosis and M. smegmatis cells with the sugar components of their surface-exposed glycans demonstrated that d-arabinose, but not α-d-glucose or d-mannose, led to the dispersion of the large clumps formed by the bacilli in stationary liquid cultures. These results confirm the presence of arabinose-containing glycans on the mycobacterial cell surface and demonstrate the implication of selective sugars in cell aggregation, suggesting that the clumping of mycobacterial cells is probably mediated by lectin-carbohydrate interactions. |
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Keywords: | Mycobacteria Tuberculosis Cell aggregation Carbohydrates |
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