Characterization of six type A strains of Clostridium botulinum that contain type B toxin gene sequences |
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Authors: | Kirma Nameer Ferreira Joseph L Baumstark Barbara R |
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Institution: | Department of Biology, P.O. Box 4010, Georgia State University, Atlanta, GA 30302-4010, USA. nkirma@emory.edu |
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Abstract: | Six Clostridium botulinum isolates exhibiting type A toxicity as measured by the mouse bioassay were found to contain both type A and type B neurotoxin DNA sequences. The six strains were divided into three groups based on the DNA sequence of the type B neurotoxin gene. Members of each group exhibited 100% sequence identity over the 3876 bp type B toxin open reading frame. The type B toxin sequence of all groups differed at more than 60 positions when compared to the BGB control strain. |
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Keywords: | Clostridium botulinum Neurotoxin gene sequence Polymerase chain reaction |
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