提高米索前列醇用于晚期妊娠引产的安全性研究

探讨提高米索前列醇用于晚期妊娠引产的安全性措施。方法：通过腹部检查，头盆评分、Ｂ超及胎心电子监护选择引产对象１２６例，随机分为两组，各６３例。２５微克组：米索前列醇２５微克阴道用药，２４小时重复一次，总量５０微克。５０微克组：米索前列醇５０微克阴道用药，２４小时重复一次，总量１００微克。

Study on Increasing Safety of Misoprostol for Induction of Labor in the Third Trimester of Pregnancy

Objective: To explore the measures for increasing safety of misoprostol for induction of labor in the third trimester of pregnancy. Method: To adopt open clinic-controlled trial. 126 selected patients were randomly derived into two groups: 25 ug (25 ug of intrav-aginal misoprostol) and 50 ug group (50 ug of that), with 63 patients for each group. The drug was inserted again after 24 hours, the total drug amounts of 50 ug and 100 ug were used in 25 ug group and 50 ug group erspectively. After contraction initiation it was put under close monitoring until the end of delivery, adopting magnesium sulphate to alleviate uterine over-efficiency within duration of labor. Observe the change of Bishop score, success rate for induction of labor, interval between drug insertion and onset of labor, total duration of labor for vaginal delivery and fetomaternal complicaiton in the two groups. Results:The success rates for induction of labor were 90. 5% for the 25 ug group, 92.1% for the 50ug group. There was no significant difference between the two groups (P>0. 05). The Bishop scores rose notably before and after drug insertion (P<0. 05), and were not singificantly different between the two groups. The interval between the first drug insertion and the total druation of labor for the vaginal delivery for 25 ug group were much longer than those for 50 fig group (P<0. 01 and P<0. 001 respectively). Incidences for uterine over-efficiency, dejecta inquination of amniotic fluid, fetal distress and neonatal asphyxia were not remarkable difference for the two groups. Conclusions: It is suitable for promoting cervical ripeness, increasing safety of misoprostal for induction of labor in the third trimester of pregnancy, that 25ug of intravaginal misoprostol was inserted and repeated again after 24 hours with total drug amounts of 50 ug. However, it is necessary to draw up the usage rule for misoprostol.