| 抗血管生成药物Endostatin作用下实体肿瘤血管网络血液灌注数值模拟 |
| |
| 引用本文： | 张洪一,吴洁,蔡彦,曹金凤,周瑜,林原,许世雄.抗血管生成药物Endostatin作用下实体肿瘤血管网络血液灌注数值模拟[J].上海生物医学工程,2009(4):187-194. |
| |
| 作者姓名： | 张洪一 吴洁 蔡彦 曹金凤 周瑜 林原 许世雄 |
| |
| 作者单位： | 复旦大学力学与工程科学系;复旦大学附属肿瘤医院; |
| |
| 基金项目： | 国家自然科学基金资助项目(10772051); 上海市重点学科建设项目(B112) |
| |
| 摘 要： | 目的研究抗血管生成治疗肿瘤主要药物之一的血管生成抑制素ES（Endostatin）对肿瘤血液灌注的影响。方法在数值生成ES作删下肿瘤血管的基础上．设血液为不可压缩牛顿流体，用扩展的Poiseuille定律和Starling定律分别计算管内流量和跨壁流量，肿瘤内间质流动遵循Darcy定律，肿瘤微血管渗透率受Endostatin的影响，用差分法数值模拟在ES作用下肿瘤血管网络的血液灌注。结果在ES作用下，肿瘤微血管生成减少，间质压力下降，压力梯度增大。结论ES药物在减少肿瘤血管生成数量的同时，改变肿瘤血管渗透性，改善肿瘤血液动力学环境，有利于其他治疗肿瘤药物的输运。
|
| 关 键 词： | 实体肿瘤 抗血管生成 Endostatin 血液灌注 数值模拟 |
Numerical Simulation of Blood Perfusion in Tumor-induced Angiogenesis under Endostatin |
| |
| ZHANG Hong-yi,WU Jie,CAI Yan,CAO Jin-feng,ZHOU Yu,LIN Yuan,XU Shi-xiong,LONG Quan.Numerical Simulation of Blood Perfusion in Tumor-induced Angiogenesis under Endostatin[J].Shanghai Journal of Biomedical Engineering,2009(4):187-194. |
| |
| Authors: | ZHANG Hong-yi WU Jie CAI Yan CAO Jin-feng ZHOU Yu LIN Yuan XU Shi-xiong LONG Quan |
| |
| Institution: | ZHANG Hong-yi1,WU Jie1,CAI Yan1,CAO Jin-feng1,ZHOU Yu1,LIN Yuan2,XU Shi-xiong,LONG Quan31Department of Mechanics and Engineering Science,Fudan University(Shanghai 200433)2Fudan University Shanghai Cancer Center(Shanghai 200032)3Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK |
| |
| Abstract: | Objective To study the effect of anti-angiogenesis drug,ES(Endostatin),on blood perfusion in tumor-induced angiogenesis.Method Based on numerical simulation of the tumor-induced angiogenesis,we assume blood as incompressible Newtonian fluid and calculate vascular flow rate and transvascular flow rate with extended Poiseuille's law and Starling's law.Interstitial flow follows Darcy's law and hydraulic permeability of the vascular wall is influenced by Endostatin.Then,we simulate the blood perfusion of tumor-... |
| |
| Keywords: | Solid Tumor Anti-angiogenesis Endostatin Blood Perfusion Numerical Simulation |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
