Modification of the aggregation state of the multifunctional enzyme complex catalyzing the first steps in pyrimidine biosynthesis in the course of development of Drosophila melanogaster |
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Authors: | Y Azou Y Mehl B P Jarry |
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Institution: | Gilmer Hall, Biology Department, University of Virginia, Charlottesville, Virginia 22901 USA |
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Abstract: | Mutations at the bithoraxoid (bxd) and postbithorax (pbx) loci cause a transformation of posterior haltere to posterior wing. It has previously been shown that pbx and cause this transformation by affecting the maintenance (or cell heredity function) of determination so that the transformed cells are indistinguishable from normal wing cells, and have no “memory” of having been part of a haltere disk (Adler, 1978a). I report here that Tp(3) and bxd1, pbx, ew both cause the transformation of posterior haltere to posterior wing in the same way as pbx. On the other hand, bxd1, , bxd51j, , and cause this same transformation of posterior haltere to posterior wing by interfering with the expression of the determined state so that the developmental information of posterior haltere is “misread” as posterior wing. The transformed cells in these disks retain the memory of having been part of a haltere disk; that is, these posterior cells that would secrete wing cuticle during metamorphosis regenerate anterior haltere structures. Thus it appears clear that it is possible to uncouple the expression and cell heredity functions of determination in the haltere disk of Drosophila. |
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Keywords: | To whom reprint requests should be addressed Present address: L G M E 11 Rue Humann 67085 Strasbourg Cédex France |
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