| 不同转移能力的肺腺癌细胞系金属蛋白酶活性分析 |
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| 引用本文： | 闫承慧,吴焱,金焰,傅松滨.不同转移能力的肺腺癌细胞系金属蛋白酶活性分析[J].遗传,2000,22(4):239-240. |
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| 作者姓名： | 闫承慧 吴焱 金焰 傅松滨 |
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| 作者单位： | 哈尔滨医科大学医学遗传学研究室,黑龙江哈尔滨 150086
Laboratory of Medical Genetics,Harbin Medical University,Harbin,Heilongjiang 150086,China |
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| 基金项目： | 黑龙江省科学技术计划攻关,青年科学基金资助项目!(Q98-9),黑龙江省科学技术计划攻关项目!(G99C20-6-1)资助 |
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| 摘 要： | 为了探讨肺腺癌细胞系中金属蛋白酶的活性与其转移能力之间的相关性，选取9个转移能力不同的肺腺癌细胞系，分别对它们所分泌的金属蛋白酶MMP－2、MMP－9进行活性分析。结果发现，金属蛋白酶的活性与肺腺癌细胞系的转移能力有一定的相关性，其中MMP－9的活性与肺腺癌细胞系的转移相关性更显著。
Abstract:To investigate the relationship between the MMP activities and metastatic ability in human lung adenocarcinoma cell lines with differential metastatic potential.Nine lung adenocarcinoma cell lines were tested for their MMP activities by zymographic analysis methods.The MMP production capabilities of carcinoma cells rose following the increase of their metastatic potentials.The result suggested that there was some relationship between MMP－9 activties and metastatic potential in human lung adenocarcinomas.
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| 关 键 词： | 肺腺癌 金属蛋白酶 Key words matrix metalloproteinases(MMP) lung adenocarcinoma |
| 修稿时间： | 2000－01－10 |
Zymographic Analysis of MMP in Human Lung Adenocarcinoma Cell Lines with Differential Metastatic Potential |
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| YAN Cheng-hui,WU Yan,JIN Yan,FU Song-bin.Zymographic Analysis of MMP in Human Lung Adenocarcinoma Cell Lines with Differential Metastatic Potential[J].Hereditas,2000,22(4):239-240. |
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| Authors: | YAN Cheng-hui WU Yan JIN Yan FU Song-bin |
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| Abstract: | To investigate the relationship between the MMP activities and metastatic ability in human lung adenocarcinoma cell lines with differential metastatic potential.Nine lung adenocarcinoma cell lines were tested for their MMP activities by zymographic analysis methods.The MMP production capabilities of carcinoma cells rose following the increase of their metastatic potentials.The result suggested that there was some relationship between MMP-9 activties and metastatic potential in human lung adenocarcinomas. |
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| Keywords: | lung adenocarcinoma matrix metalloproteinases(MMP) |
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