| CRISPR-Cas系统与细菌和噬菌体的共进化 |
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| 作者姓名： | Li TM Du B |
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| 作者单位： | 辽宁大学生命科学院,沈阳,110036 |
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| 基金项目： | 沈阳市科技局计划项目(编号:1091187-1-00)资助 |
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| 摘 要： | 细菌在适应噬菌体攻击的过程中,进化了多种防御系统,噬菌体在细菌的选择压力下,也在不断进化反防御策略,双方的这种进化关系与发生机制一直尚不完全清楚。近年在细菌和古细菌中发现一种新的免疫防御系统,即CRISPR-Cas(clustered regularly interspaced short palindromic repeats-CRISPR-associated system)系统。在对其功能和作用机制深入研究的同时,也不断地揭示了细菌和噬菌体之间的共进化关系。为此,文章在介绍原核细胞中CRISPR-Cas系统介导的免疫机制基础上,重点综述了CRISPR系统在细菌和噬菌体进化中的作用。
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| 关 键 词： | CRISPR CRISPR-Cas系统 噬菌体 共进化 免疫防御 |
CRISPR-Cas system and coevolution of bacteria and phages |
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| Li TM,Du B.CRISPR-Cas system and coevolution of bacteria and phages[J].Hereditas,2011,33(3):213-218. |
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| Authors: | Li Tie-Min Du Bo |
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| Institution: | LI Tie-Min,DU Bo College of Life Science,Liaoning University,Shenyang 110036,China |
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| Abstract: | In response to the challenge from phages,bacteria evolve a number of defense systems against phage invasion.Meanwhile,the phages evolve multiple counter-defense mechanism as well under the selection pressure from bacteria.The evolution relationship between bacteria and phages,as well as the functional mechanism,still remains to be uncovered.A novel immune system,CRISPR-Cas system,has been found in bacteria and archaea recently.With deeply research of the function and mechanism of CRISPR-Cas system,the coevo... |
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| Keywords: | CRISPR CRISPR-Cas system phage coevolution immune defense |
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